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Examination offered in prenatal cytogenetic diagnostics Our workplace offers chromosome fetus examination in the 1^st and 2^nd trimester of gravidity 1^st trimester of gravidity CVS (chronic villi sampling) – chromosome examination carried out on chorionic tissue utilizing spontaneous mitotic activity of dividing syncytiotrophoblast, so called direct method, giving the result within 48 hours. This method is suitable especially for detecting numerical chromosome abnormalities and establishing fetus sex. At the same time cultivation of chorionic tissue cells is carried out. This requires a longer time period, but it gives results comparable with cell cultivation of amniotic fluid. Collection is carried out trans-abdominally in the 12^th – 13^th week of gravidity. 2^nd trimester of gravidity Amniocentesis – chromosome examination carried out from cultivated cells of amniotic fluid. Collection is made trans-abdominally in the 14^th – 24^th week of gravidity. The results are available within 18 days according to the growth properties of the cultures. The method is suitable for both elimination of aneuploidies and structural aberrations. In latter weeks of gravidity it is good to combine it with some fast methods (FISH, GF, PCR) for fast detection of aneuplodies when the result is available within three days. Cordocentesis – Collection of fetal blood from umbilical cord is carried out in special cases from approximately the 20^th week of gravidity. The result is available within one week after collection. The examination is suitable especially for detection of serious fetus malformations or in fetus detected at UZ, or when mosaics are found in the prime culture.